Catalog Number:
200-06
Synonyms:
26 kDa protein,IFN-β2,B cell differentiation factor （BCDF）,BSF-2,HPGF,HSF,MGI-2
Description:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and plaet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
AA Sequence:
PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107units/mg.
Cross Reactivity:
Monkey, Mouse, Rat
IL-6主要由T,B細(xì)胞和單核巨噬細(xì)胞分泌的細(xì)胞因
子.在機(jī)體的炎癥反應(yīng)和免疫調(diào)節(jié)過(guò)程中發(fā)揮重要作用,
可協(xié)同IL-1的免疫調(diào)節(jié)作用.IL-1,IL-6在AA發(fā)病
中是潛在的破壞骨樣細(xì)胞增長(zhǎng)的刺激因子.它們作為重要
的炎癥,免疫介導(dǎo)因子參與AA的病理過(guò)程.
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